Dermatographism With Genital Symptoms Treated With Antihistamines: A Case Series
Bibliographic record
Abstract
gangrenosum with acne and hidradenitis suppurativa (PASH) syndrome (3%).Adverse events were infrequently reported, with only 2 cases reporting a generalized maculopapular skin rash and bone marrow toxicity.Among cases that reported details of sulfasalazine therapy, the most common daily dosage was 1 g (range: 1-6 g).Mezavant formulation was mentioned in 4 studies, with only 2 detailing dosages of 2 and 4 g/day.Sulfasalazine usage duration varied considerably, averaging 11.6 weeks (range: 1-32 weeks; Supplemental Table 1).Notably, sulfasalazine was used concomitantly with another therapy in 85% of cases.Glucocorticoids were the most prevalent concurrent therapy, typically prescribed at a daily dose of 80 mg/ day (range: 20-80 mg/day).Antibiotics and azathioprine (100 mg/day; range: 100-150 mg/day) were also frequently employed in combination with sulfasalazine.Treatments for PG prior to sulfasalazine initiation included antibiotics, glucocorticoids, and dapsone, of which all except 2 cases reported no benefit.This review is limited by potential biases inherent to the included studies such as a publication bias, incomplete reporting, and confounding by indication.Although sulfasalazine was noted to be largely effective, its benefits for PG might be linked to improving a co-existing IBD.Among 11 cases reporting PG improvement in IBD patients, 55% also noted concurrent IBD improvement.In consideration of the positive outcomes reported in patients with PG treated with adjunct sulfasalazine, without apparent adverse events, we suggest that systemic sulfasalazine can be an effective option for the treatment of PG, especially when associated with IBD.This underscores the need for prospective studies to assess sulfasalazine's clinical utility in PG treatment.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".