STUDY OF ANTIOXIDANT ACTIVITY OF CARBON DIOXIDE GAS ON THE MODEL OF THE ACUTE INFLAMMATORY REACTION
Bibliographic record
Abstract
Introduction.Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by multiple motor and non-motor symptoms that lead to a deterioration in the patients' quality of life.It is important to understand how different domains differ in PD patients to improve their quality of life.The aim of our study was to assess cognitive and motor impairment in different motor subtypes of PD and analyze their relationship with quality of life.Object and methods.The study included 64 patients with Parkinson's disease, who were divided according to the motor subtype: group 1 -patients with PD subtype with predominance of postural instability and gait disorders (PIGD), group 2 -patients with PD subtype with predominance of tremor or intermediate subtype (non-PIGD).The Unified Parkinson's Disease Rating Scale, the Hoehn and Yahr scale, the Montreal Cognitive Assessment, and the The Parkinson's Disease Questionnaire (PDQ-39) were used to examine patients.Results.We did not find statistically significant differences in the severity of various domains of clinical manifestations, complications of levodopa therapy and cognitive impairment in patients with different motor subtypes of PD.At the same time, patients with PIGD subtype of PD are more prone to higher values of the Hoehn and Yahr stage.It was found that group 1 had a statistically significantly higher score on the «mobility» (p=0.004) and «emotional well-being» (p=0.013)scales, indicating a greater severity of motor function disorders and psychoemotional disorders in these patients.At the same time, it was found that the score on the «stigmatization» scale was higher in group 2 (p=0.049).There were no differences in the scales of «daily activity», «social support», «cognition», «communication» and «body discomfort».The total score on the PDQ-39 scale was higher in group 1 compared to group 2 (p=0.042),indicating a worse quality of life.It is presented that the quality of life of patients with CP is closely related to cognitive and motor impairment.At the same time, it has been demonstrated that even with comparable severity of clinical manifestations and cognitive impairment, the PIGD phenotype is associated with poorer quality of life, which may indicate the potential role of non-motor symptoms in causing this phenomenon.Conclusions.We found a poorer quality of life in patients with PIGD subtype of PD, in particular in the domains of mobility and emotional well-being, while patients with non-PIGD subtype were characterized by a more acute perception of disease stigma, in the absence of differences in the severity of clinical symptoms and cognitive impairment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".