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Record W4393169360 · doi:10.5505/kpd.2024.55632

Clinical, genetic, and epigenetic markers associated with lithium response in bipolar disorder

2024· article· en· W4393169360 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Clinical Psychiatry · 2024
Typearticle
Languageen
FieldMedicine
TopicBipolar Disorder and Treatment
Canadian institutionsStantec (Canada)
Fundersnot available
KeywordsBipolar disorderEpigeneticsLithium (medication)MedicineGeneticsBiologyInternal medicineGene

Abstract

fetched live from OpenAlex

Bipolar bozuklukta lityum yantyla ilikili klinik, genetik ve epigenetik belirtelerClinical, genetic, and epigenetic markers associated with lithium response in bipolar disorder ZET Bipolar bozukluk yaam kalitesinde azalma ve ilevsellik kaybna neden olan, kronik seyirli ve yaygn bir psikiyatrik hastalktr.Lityum, bipolar bozukluun akut mani ve srdrm tedavisinde ilk sradaki yerini korumakla birlikte lityumun etki mekanizmalar gnmzde hala net olarak bilinmemektedir.Ayrca lityum yant hastalar arasnda yksek oranda deikenlik gstermektedir.Bipolar bozuklukta %30-55 kadar hasta lityum tedavisinden fayda grmemekte veya tedaviyi brakmasna neden olan yan etkiler yaamaktadr

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.116
Threshold uncertainty score0.557

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.378
Teacher spread0.350 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it