Anemia at discharge from pediatric intensive care unit : prevalence, risk markers and management
Bibliographic record
Abstract
Anemia is frequent at pediatric intensive care unit (PICU) admission and during PICU stay, and it is associated with bad outcomes during critical illness. Moreover, restrictive transfusional strategies are currently recommended for most of the critically ill children. Therefore, it makes sense to wonder about anemia at discharge from PICU.This is a relevant question: indeed, anemia is associated with worse outcomes in several non-critical settings. It is thus plausible that anemia at PICU discharge is associated with bad post-PICU outcomes, which is particularly relevant nowadays considering the low mortality rate reported in PICU.The main finality of our research program is the association between post-PICU anemia and post-PICU outcomes, and eventually the impact of the treatment of anemia on post-PICU outcomes. However, to date, published data on anemia at discharge from PICU are almost non-existent. The first step of our research program is thus to obtain a global picture of the current situation: this is the aim of this thesis.The objectives of this thesis are to determine the prevalence of anemia at discharge from PICU, its risk markers, and its management by pediatric intensivists. To reach these goals, we plan to conduct three studies: a prospective monocenter study including a cohort of children admitted during a 1-year period in a tertiary PICU in Montreal, Canada; a retrospective bi-center study including a cohort of children admitted during a 5-year period in the tertiary PICUs of Lille and Lyon; and an international survey distributed to PICU physicians across the world and aiming to assess their prescriptions of red blood cells, iron and erythropoietin to children anemic at PICU discharge.These studies are required to assess the importance of the problem, to identify subgroups of children at risk of anemia after critical illness, to raise hypotheses on the causes of this anemia, and to determine the way pediatric intensivists perceive and treat discharge anemia (do they treat it like they treat anemia during the acute phase of critical illness?). These data will help to construct future studies on this topic and to interpret the results of these future studies.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.006 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".