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Record W4393673708 · doi:10.5281/zenodo.8008094

CFdb: chromatograms

2023· dataset· en· W4393673708 on OpenAlexaff
Michael A. Skinnider

Bibliographic record

VenueZenodo (CERN European Organization for Nuclear Research) · 2023
Typedataset
Languageen
FieldImmunology and Microbiology
TopicBiosimilars and Bioanalytical Methods
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsChromatographyChemistry

Abstract

fetched live from OpenAlex

This upload contains processed chromatogram matrices for 411 CF-MS experiments. Database search and protein quantitation was performed with MaxQuant (version 1.6.5.0), and potential contaminants, reverse hits, and proteins identified only by modified peptides were filtered out. Multiple chromatograms are provided for each experiment, corresponding to different protein quantitation strategies. These include iBAQ, MaxLFQ, MS1 intensity, and spectral counts, for label-free datasets, and the isotopologue ratio for SILAC or dimethyl labelling datasets. Each directory also contains a metadata file, which contains further information about each row in the corresponding chromatogram matrices output by MaxQuant. Chromatograms are also provided for phosphorylation sites detected in a separate MaxQuant search including STY phosphorylation as a variable modification (in the "Phosphorylation" directory). Separate chromatograms are provided for raw phosphosite intensities and the ratio between modified and unmodified phosphosite intensities (phosphorylation stoichiometries). For datasets collected with SILAC or dimethyl labelling, isotopologue ratio chromatograms are also provided. For TMT datasets, reporter intensities for phosphosites were not output by MaxQuant, meaning that only aggregate measurements of phosphosite intensity and stoichiometry over all experiments in the TMT plex could be obtained. In addition to processed chromatograms, which are provided in the "Chromatograms" directory, the upload also contains the raw output files ('proteinGroups.txt' and 'Phospho(STY) sites.txt') from each MaxQuant search. These files are provided within the "Protein groups" directory. Complete MaxQuant outputs for each experiment are available from the PRIDE repository (see the manuscript for accession).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.132
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0020.000
Scholarly communication0.0000.000
Open science0.0020.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0420.174

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.292
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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