Dipeptidyl peptidase 11 (PgDPP11); A Target Enabling Package
Bibliographic record
Abstract
<em>Porphyromonas</em> gingivalis (<em>P. gingivalis</em>) is the main causative agent of Periodontitis, the most widespread inflammatory condition world-wide. Recently this organism has been implicated in several systemic conditions, such as Alzheimer’s disease and type 2 diabetes. <em>P. gingivalis</em> does not ferment carbohydrates, instead it uses proteases to generate energy and carbon source. Dipeptidyl peptidase 11 plays a central role in the energy metabolism of this bacterium and has been proposed as an attractive drug target. This TEP provide early tools to develop inhibitors of PgDPP11, including purification protocols of recombinant proteins, a crystal structure of the protein in complex with a dipeptide, crystallisation conditions suitable for crystallography-based fragment screening, an inhibition assay and fragment hits in the active site and an allosteric site. These molecules provide a promising starting point for the development of more specific and potent PgDPP11 inhibitors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.003 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.635 | 0.014 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".