Contemporary conditional cancer‐specific survival rates in surgically treated nonmetastatic primary urethral carcinoma
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Bibliographic record
Abstract
Abstract Background We examined the effect of disease‐free interval (DFI) duration on cancer‐specific mortality (CSM)‐free survival, otherwise known as the effect of conditional survival, in radical urethrectomy nonmetastatic primary urethral carcinoma (PUC) patients. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database 2000–2020, patient (age, sex, race/ethnicity, and marital status) and tumor (stage and histology) characteristics, as well as systemic therapy exposure status of nonmetastatic PUC patients were tabulated. Conditional survival estimates at 5‐year were assessed based on DFI duration and according to stage at presentation (T 1 –2 N 0 vs. T 3–4 N 0–2 ). Results Of all 512 radical urethrectomy PUC patients, 278 (54%) harbored T 1–2 N 0 stage versus 234 (46%) harbored T 3–4 N 0–2 stage. In 512 PUC patients, 5‐year CSM‐free survival at initial diagnosis was 61.8%. Provided a DFI duration of 36 months, 5‐year CSM‐free survival was 85.6%. In 278 T 1–2 N 0 PUC patients, 5‐year CSM‐free survival at initial diagnosis was 68.4%. Provided a DFI duration of 36 months, 5‐year CSM‐free survival was 86.9%. In 234 T 3–4 N 0–2 PUC patients, 5‐year CSM‐free survival at initial diagnosis was 53.8%. Provided a DFI duration of 36 months, 5‐year CSM‐free survival was 83.6%. Conclusions Although intuitively, clinicians and patients are well aware of the concept that increasing DFI duration improves survival probability, only a few clinicians can accurately estimate the magnitude of survival improvement, as was done within the current study. Such information is crucial to survivors, especially in those diagnosed with rare malignancies, where the survival estimation according to DFI duration is even more challenging.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it