Professor Philippe Crine: a hero for children with hypophosphatasia
Bibliographic record
Abstract
Philippe Crine 1946 - 2023. Philippe Crine, the father of asfotase alfa treatment for hypophosphatasia (HPP), died on June 13, 2023 at the age of 76. Medical research has lost a great biochemist, a pioneer, and a visionary who conceptualized and developed a miracle therapy for HPP,1,2 the genetic disorder from mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase.2 HPP features poorly mineralized bones that fracture and deform, often with lifelong handicap and sometimes death in infancy. Philippe Crine was born in Belgium and emigrated to Canada in 1968 for graduate studies at the Université de Montréal under Pr. Walter Verly. After his PhD (1974), he moved to Brandeis University to study DNA repair. In 1975, his curiosity was attracted by the discovery of enkephalin/endorphin neuropeptides and he joined Pr. Michel Chrétien at the Institut de recherches cliniques de Montréal to study endorphins. He was the first to show how β-endorphin is made enzymatically from ProOpioMelanoCortin. From there, molecular enzymology and protein chemistry became the focus of Philippe’s research. In 1978, he joined the Department of Biochemistry at the Université de Montréal as professor, later as Chair of the department (1989-1997), and then vice-dean of research at the Faculty of Medicine (1999-2002).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.002 | 0.012 |
| Insufficient payload (model declined to judge) | 0.028 | 0.009 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".