58 Objective and Subjective Melanin Measurements Within Dyschromic Scars Do Not Correlate: A Treatment Evaluation Problem
Bibliographic record
Abstract
Abstract Introduction Dyschromia, the presence of hyper- and/or hypopigmented epidermis, is a common result of burn injury and is associated with negative aesthetic outcomes. Three clinical scales, the Patient and Observer Scar Assessment Scale - Patient (POSAS-P), Patient and Observer Scar Assessment Scale - Observer (POSAS-O), and modified Vancouver Scar Scale (mVSS) are used to evaluate dyschromia when assessing treatment options and outcomes. However, these assessment tools have yet to be validated against objective scar tissue melanin measurements. We hypothesize that these scar scales do not adequately capture pigmentation changes, necessitating more accurate metrics for clinical assessment. Methods Patients (n=98) with dyschromic burn scars due to thermal, chemical, electrical, or friction burns were recruited from a local burn center. Scars were rated on the POSAS-P, POSAS-O, and mVSS and the melanin content of uninjured skin and hyper-pigmented scar tissue was assessed using a Skin Color Catch non-invasive probe. The “degree of hyperpigmentation” (DOH) was calculated by the change in melanin content from the normal skin (NS) to the hyper-pigmented scar tissue, which was tested for correlation with POSAS-P-color and POSAS-O-pigmentation scores. The DOH between scars in each of the four categories of the mVSS-pigment was compared. For POSAS-P and POSAS-O, a higher score indicates more dyschromia. For mVSS, dyschromia is categorized. Results Hyperpigmented scars were on average 96.08±6.08 Melanin Index points higher than NS. Observers rated hyperpigmented scars high at 7.14±0.28 while patients rated higher at 7.67±0.24 (both out of 10). The most common mVSS-pigment category observed was 2, mixed pigmentation. The correlations between POSAS-P-color and DOH and POSAS-O-pigmentation and DOH were not significant (r=-0.033, p=0.7455 and r=-0.12, p=0.2323). Additionally, there were no significant differences in melanin index means between scars in the four mVSS-pigment categories (p < 0.05). Conclusions The non-significant correlation between the scoring value from the POSAS-P, POSAS-O, and mVSS with DOH indicate that these tools do not adequately capture degree of dyschromia in patients with dyspigmentation following burn injury. Applicability of Research to Practice The data from these scales should not solely be used to evaluate treatment effect.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.018 | 0.055 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".