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Record W4395022322 · doi:10.1093/ajhp/zxae110

Recommendations for pharmacogenetic testing in clinical practice guidelines in the US

2024· review· en· W4395022322 on OpenAlexaff
Daniel L. Hertz, Chad Bousman, Howard L. McLeod, Andrew A. Monte, Deepak Voora, Lori A. Orlando, Rustin D. Crutchley, Benjamin Brown, Wrenda Teeple, Sara Rogers, Jai N. Patel

Bibliographic record

VenueAmerican Journal of Health-System Pharmacy · 2024
Typereview
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicPharmacogenetics and Drug Metabolism
Canadian institutionsUniversity of Calgary
FundersNational Institute of General Medical SciencesNational Institutes of Health
KeywordsPharmacogeneticsClinical PracticeMedical physicsMedicinePsychologyEngineering ethicsFamily medicineEngineeringBiologyGeneticsGenotype

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.034
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.942
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0340.003
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0010.003
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0020.000
Research integrity0.0000.005
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.580
GPT teacher head0.661
Teacher spread0.080 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2024
Admission routes1
Has abstractyes

Explore more

Same venueAmerican Journal of Health-System PharmacySame topicPharmacogenetics and Drug MetabolismFrench-language works237,207