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Record W4395465417 · doi:10.18280/ijdne.190206

Acute Toxicity of Aluminum, Cobalt, and Lithium Chlorides in Albino wistar Mice: Determination of Lethal Doses

2024· article· en· W4395465417 on OpenAlexvenueno aff
Wasan Abdulmunem Taha, Sura Samir Mohammed, Lubna Samir Mohammed

Bibliographic record

VenueInternational Journal of Design & Nature and Ecodynamics · 2024
Typearticle
Languageen
FieldMedicine
TopicPhytochemicals and Medicinal Plants
Canadian institutionsnot available
Fundersnot available
KeywordsToxicityLithium (medication)Acute toxicityCobaltToxicologyPharmacologyLithium chlorideMedian lethal doseChemistryMedicineBiologyInternal medicineInorganic chemistry

Abstract

fetched live from OpenAlex

Chlorides are considered one of the dangerous pollutants that pose a threat to human and animal health.The study aims to determine the acute lethal doses (LD50) of aluminum, cobalt, and lithium chlorides in Albino wistar mice.Albino wistar mice were divided into four groups with the mice were randomly divided into 4 groups, 8 mice for experimental group and 6 mice for control group.Short tests were conducted to determine the acute lethal dose of the metals under study.Over 168 hours, mice were exposed to four different concentrations of (AlCl2) metal in concentrations of 40, 50, 60 and 70 mg/kg per liter of water, where 1 liter of water was placed in each bottle, while the second group was exposed to cobalt chloride (CoCl2) in concentrations 75, 100, 125 and 150 mg/kg per liter of water, where 1 liter of water was placed in each bottle.As well as, the third group, it was exposed to (LiCl2) at concentrations 75, 100, 125 and 150 mg/kg per liter of water, while the fourth group included the control group. 1 liter of water was placed in each bottle and it was given orally.LC50 was calculated by use Finney's probit analysis method where LC50 it is abbreviation "lethal concentration 50%" or "intermediate lethal concentration".It is the concentration of a material (in the water) which it killed a half the members of populations after a specific during of exposed to toxic metal.This value is so importance in toxicology because it gives an indicated of materials poisoning.The LC50 is inverse proportionate to toxicity.The current study concluded the dose that killed 50% of the Albino wistar mice was 50mg/kg of AlCl2, 100mg/kg of CoCl2, while it was 125mg/kg of lithium chloride.Long-term use of greater doses of chlorides can have varying degrees of negative impact on various organs in mice.This study provides context for a more thorough investigation of the toxicity of chlorides compounds on humans, which may be significant for public health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.146
Threshold uncertainty score0.339

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.294
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

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