A Portable, Rapid Isothermal Nucleic Acid Amplification System with Integrated Microfluidics for Pandemic Surveillance
Bibliographic record
Abstract
Integration of small-footprint cost-effective isothermal rapid DNA extraction, ampliőcation, and detection systems is crucial to achieving a point-of-care pathogen detection system suitable for resource-limited locations.The herein system measures low-level ŕuorescent signals in real-time during nucleic acid ampliőcation, while maintaining the desired assay temperature on a low-power, portable footprint.A thermally stable microŕuidic device was implemented to mitigate thermocapillary effects and facilitate optical alignment for automated image capture and signal analysis.I would like to thank Professor Ravi Prakash for his invaluable advice, help, and support as a supervisor throughout my graduate studies.The work achieved would not have been possible without his vision and expertise in the vast areas of science and engineering.I am extremely grateful to have been able to work on this high-impact project that has given me the experience to continue my career in the healthcare technology őeld.I want to thank all of my colleagues at the Organic Sensors
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".