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Record W4396586540 · doi:10.1111/aas.14435

Fast‐track spinal anaesthesia reduces length of motor blockade and facilitates earlier discharge after joint arthroplasty

2024· letter· en· W4396586540 on OpenAlexaff
Ryan Endersby, Vivian Ip, Joanna J. Moser, Andrew Walker, Leyla Baghirzada, Adam O. Spencer, Esther Ching Yee Ho

Bibliographic record

VenueActa Anaesthesiologica Scandinavica · 2024
Typeletter
Languageen
FieldMedicine
TopicAnesthesia and Pain Management
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsMedicineJoint arthroplastyAnesthesiaFast trackSpinal anesthesiaArthroplastyBlockadeRegional anaesthesiaGeneral anaesthesiaSurgeryInternal medicine

Abstract

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We read with interest the study protocol by Jensen et al.1 We applaud their effort in evaluating the mobility of patients within 6 h following surgeries in ambulatory total joint replacement, including total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty after different types of anaesthesia. Herein, we would like to highlight that the evolution of spinal anaesthesia (SA) might impact the outcome of the study. There has been renewed interest in shorter acting local anaesthetics (LA) other than the traditional and ubiquitously used bupivacaine. These shorter acting LA have been used extensively for fast-track and ambulatory surgery programmes. Perhaps of greatest interest in the setting of SA for THA and TKA is mepivacaine. Several recent studies using spinal mepivacaine for THA and TKA have shown an earlier return of motor function and ambulation, shorter length of stay and decreased urinary retention compared with spinal bupivicaine.2-7 Early research on other short-duration LA of chloroprocaine and ropivacaine also showed promising outcomes.8, 9 Bupivacaine may be the least well-suited LA for fast-track arthroplasty. We believe it is comparable to using older, longer lasting general anaesthetics instead of our more rapidly eliminated general anaesthetic agents used in current practice. A few studies have examined using low doses of bupivacaine (3.5–5 mg) for TKA with favourable results on duration of SA.10, 11 These studies however did not examine THA whereby these lower doses may not produce adequate sensory and motor blockade for surgery.10, 11 As well some of these studies had significant analgesic supplementation or conversion to general anaesthesia (GA) with the low doses or utilised additional regional anaesthesia blockade with sciatic and femoral nerve blocks, which may further impede postoperative ambulation.10, 11 Further the formulation of bupivacaine, being either isobaric or hyperbaric can impact the duration of sensory and motor block. A recent meta-analysis has found the isobaric formulation to have a longer duration of both sensory and motor block.12 The cost associated with the anaesthetic technique, both in monetary terms and their impact on the environment, should also be considered. SA has been shown to reduce costs and is associated with a lower environmental impact when compared with volatile GA agents which are potent greenhouse gases.13, 14 This is particularly important as healthcare is one of the major contributors to greenhouse gas emissions and many healthcare systems are considering reducing carbon footprint such as our health services in Alberta, or moving towards net zero healthcare, for example, the National Health Services in the United Kingdom, as their priority. While many studies have recently emerged to investigate the differences between GA and SA in morbidity and mortality in THA/TKA, we congratulate the authors in taking this investigation from a different angle.1 Nonetheless, we would encourage researchers to consider using newer fast-track SA techniques for these studies, while taking into account of the duration of surgery. Other important considerations in terms of outcome measures include both the monetary perspective and planet health. All of the authors contibuted to this paper. None. I have no conflicts of interest to declare. Data sharing is not applicable – no new data generated.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.040

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.013
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0130.008
Insufficient payload (model declined to judge)0.0120.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.251
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2024
Admission routes1
Has abstractyes

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