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Record W4396607049 · doi:10.1016/j.jscai.2024.101868

LB-2 | VEGF Gene Therapy Improves Exercise Time, Ischemia, and Symptoms in Patients with Refractory Angina: Results of the Phase II EXACT Trial

2024· article· en· W4396607049 on OpenAlexaff
Kenta Nakamura, Timothy D. Henry, Jay H. Traverse, David A. Latter, Nahush A. Mokadam, Geoffrey A. Answini, Adam Williams, Benjamin Sun, Christopher R. Burke, Faisal G. Bakaeen, Marcelo F. DiCarli, Bernard Chaitman, Mark W. Peterson, Dawn G. Byrnes, E. Magnus Ohman, Carl J. Pepine, Ronald G. Crystal, Todd K. Rosengart, Elaine K. Kowalewski, Gary G. Koch, Howard C. Dittrich, Thomas J. Povsic

Bibliographic record

VenueJournal of the Society for Cardiovascular Angiography & Interventions · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAngiogenesis and VEGF in Cancer
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
Fundersnot available
KeywordsVEGF receptorsRefractory (planetary science)MedicineAnginaInternal medicineGenetic enhancementIschemiaCardiologyPhysical therapyStable anginaOncologyGeneCoronary heart diseaseMaterials scienceMyocardial infarctionBiology

Abstract

fetched live from OpenAlex

XC001 is a novel adenoviral-5 vector designed to express multiple isoforms of vascular endothelial growth factor to more safely and potently induce angiogenesis. The EXACT trial (NCT04125732) assessed the safety and preliminary efficacy of XC001 in patients with “no option” refractory angina (NORA).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.253
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

Same venueJournal of the Society for Cardiovascular Angiography & InterventionsSame topicAngiogenesis and VEGF in CancerFrench-language works237,207