FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.366
- Threshold uncertainty score
- 0.423
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.221 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
FMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors. Counts of B cells, monocytes, and DCs were low in the patients' blood, whereas the other blood subsets, including NK cells, were affected only moderately, if at all. The patients had normal counts of Langerhans cells (LCs) and dermal macrophages in the skin but lacked dermal DCs. Thus, FLT3L is required for B cell and DC development in mice and humans. However, unlike its murine counterpart, human FLT3L is required for the development of monocytes but not NK cells.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Cell
- Topic
- Immune Cell Function and Interaction
- Field
- Immunology and Microbiology
- Canadian institutions
- McGill UniversityMcGill Genome Centre
- Funders
- H2020 European Research CouncilPenn State Hershey Cancer InstituteNational Cancer InstituteNational Institute of Dental and Craniofacial ResearchEuropean Research CouncilNational Center for Advancing Translational SciencesMedical Research CouncilNational Institutes of HealthFonds de dotation CSL Behring pour la rechercheFondation Bettencourt SchuellerSociété Française de Dermatologie et de Pathologie Sexuellement TransmissibleHoward Hughes Medical InstituteVetenskapsrådetGlenn Foundation for Medical ResearchHonjo International Scholarship FoundationAgence Nationale de Recherches sur le Sida et les Hépatites ViralesKU LeuvenFondation pour la Recherche MédicaleSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesSociété Francophone du DiabèteAgence Nationale de la RechercheCSL BehringDivision of Intramural Research, National Institute of Allergy and Infectious DiseasesGöran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk ForskningFonds Wetenschappelijk OnderzoekStavros Niarchos FoundationSchlumberger FoundationNHLBI Division of Intramural ResearchUniversity of PennsylvaniaLEO FondetScience for Life LaboratoryRockefeller UniversityInstitut National de la Santé et de la Recherche MédicaleGöran Gustafssons StiftelserSt. Giles FoundationVlaamse regeringPennsylvania State UniversityNational Health and Medical Research CouncilFondation Schlumberger pour l’Education et la RechercheInstitut National Du CancerAmerican Association of Immunologists
- Keywords
- BiologyHaematopoiesisBone marrowImmunologyProgenitor cellMyeloidDendritic cellCell biologyImmune systemStem cell
- Has abstract in OpenAlex
- yes