Multiple Metastatic Lesions on a Post-Ablative Whole-Body Scan Despite a Negative Serum Thyroglobulin Level in a Patient With Papillary Thyroid Cancer
Bibliographic record
Abstract
Serum thyroglobulin (Tg) and radioactive iodine (RAI) whole-body scan (WBS) have been used to detect recurrent and metastatic differentiated thyroid cancer after total thyroidectomy and RAI remnant ablation. Discordant results of serum Tg and WBS are occasionally encountered, and a negative serum Tg and positive WBS are less common than a positive serum Tg and negative WBS. The author reports a rare case of a 41-year-old man with papillary thyroid cancer who showed unsuspected multiple metastatic lesions in both cervical lymph nodes and both lungs on post-ablative WBS despite a negative stimulated serum Tg level after total thyroidectomy and that an initial negative stimulated serum Tg level was converted to positive after RAI remnant ablation. In conclusion, RAI WBS can contribute to the detection of a relatively small number of unsuspected local and distant metastases despite a negative stimulated serum Tg. J Endocrinol Metab. 2024;14(2):78-84 doi: https://doi.org/10.14740/jem940
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".