Long-term intake of corn gluten meal protein hydrolysate attenuated hypertension development and modulated associated plasma metabolite levels in spontaneously hypertensive rats
Bibliographic record
Abstract
This study evaluated the long-term antihypertensive effect of corn gluten meal protein hydrolysate (CGM-H) on spontaneously hypertensive rats (SHRs). Plausible pathways governing blood pressure were also evaluated based on untargeted metabolomic analysis. The casein diet containing 1 % of CGM-H and peptides obtained from ultrafiltration membranes attenuated the development of hypertension in SHRs after a 6-week oral administration with similar efficacy, while the control group showed progressive hypertension. Plasma renin and angiotensin converting enzyme (ACE) activity and total peroxides level of the corn peptides-treated groups decreased when compared with the control (p < 0.05). In addition, the corn peptides up-regulated antihypertensive metabolites such as prostaglandin K2 and 11-ketotestosterone, while corticosterone, biotin, and plasma fatty acids were down-regulated. This study demonstrates that corn peptides did not only inhibit ACE and renin activities, but also modulated the biosynthesis and metabolisms of fatty acids, sex hormones, and aldosterone, which would have contributed to attenuation of hypertension.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".