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Record W4396863977 · doi:10.1038/s41588-024-01732-8

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

2024· article· en· W4396863977 on OpenAlexaff
Matthew R. Lincoln, Noah Connally, Pierre‐Paul Axisa, Christiane Gasperi, Mitja Mitrovič, David A. van Heel, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers, Leonid Padyukov, Ashley Beecham, Nikolaos A. Patsopoulos, Chris Cotsapas, David R. Booth, An Goris, Annette Oturai, Janna Saarela, B. Fontaine, Bertrand Hemmer, Martin Claes, Frauke Zipp, Sandra D’Alfonso, Filippo Martinelli Boneschi, Bruce Taylor, Hanne F. Harbo, Ingrid Kockum, Jan Hillert, Tomas Olsson, Rogier Hintzen, Lisa F. Barcellos, Lars Alfredsson, Federica Esposito, Roland Martinꝉ, Jonathan L. Haines, Margaret A. Pericak‐Vance, Adrian J. Ivinson, Graeme J. Stewart, David A. Hafler, Stephen L. Hauser, Alastair Compston, Gil McVean, Philip L. De Jager, Stephen Sawcer, Jakob L. McCauley, Stephen S. Rich, Robert Graham, Patrick M. Gaffney, Carl D. Langefeld, Timothy J. Vyse, Sung Chun, Shamil Sunyaev

Bibliographic record

VenueNature Genetics · 2024
Typearticle
Languageen
FieldImmunology and Microbiology
TopicT-cell and B-cell Immunology
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
FundersNational Institute of Neurological Disorders and StrokeNational Institute of Allergy and Infectious DiseasesNational Institute of General Medical SciencesWeill Institute for Neurosciences, University of California, San FranciscoNational Institute of Mental HealthIrving Medical Center, Columbia UniversityUniversity of California, San FranciscoUniversity of OxfordNational Multiple Sclerosis SocietyGenentechMenzies Institute for Medical ResearchUniversità degli Studi del Piemonte OrientaleOklahoma Medical Research FoundationKarolinska InstitutetDeutsche ForschungsgemeinschaftNational Human Genome Research InstituteNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome TrustRijksuniversiteit GroningenUniversity of TasmaniaNational Institute of Child Health and Human DevelopmentNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesLupus Research AllianceHarvard NeuroDiscovery CenterU.S. Department of Health and Human ServicesCase Western Reserve UniversityUniversità degli Studi di Milano
KeywordsBiologyAlleleGeneticsQuantitative trait locusMechanism (biology)Computational biologyGenome-wide association studyEvolutionary biologyGeneGenotypeSingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.844
Threshold uncertainty score0.926

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.252
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations34
Published2024
Admission routes1
Has abstractno

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