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Record W4396922010 · doi:10.1016/j.chom.2024.04.016

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

2024· article· en· W4396922010 on OpenAlexaff
Fabienne Benz, Sarah Camara-Wilpert, Jakob Russel, Katharina G. Wandera, Rimvydė Čepaitė, Manuel Ares-Arroyo, José Vicente Gomes‐Filho, Frank Englert, Johannes A. Kuehn, Silvana Gloor, Mario Rodríguez Mestre, Aline Cuénod, Mònica Aguilà-Sans, Lorrie Maccario, Adrian Egli, Lennart Randau, Patrick Pausch, Eduardo P. C. Rocha, Chase L. Beisel, Jonas Stenløkke Madsen, David Bikard, Alex R. Hall, Søren J. Sørensen, Rafael Pinilla‐Redondo

Bibliographic record

VenueCell Host & Microbe · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsMcGill University
FundersHorizon 2020Vilnius UniversityH. Lundbeck A/SHorizon 2020 Framework ProgrammeNovo Nordisk FondenNovo NordiskInstitut PasteurLundbeckfondenEidgenössische Technische Hochschule ZürichAgence Nationale de la RechercheEuropean Regional Development FundEuropean CommissionDeutsche ForschungsgemeinschaftInfrastructures en Biologie Santé et AgronomieSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungLietuvos Mokslo TarybaOxford Nanopore TechnologiesVillum FondenUniversity of Otago
KeywordsPlasmidCRISPRBiologyHorizontal gene transferGeneticsGeneRibonucleoproteinCas9Klebsiella pneumoniaeComputational biologyRNAEscherichia coliGenome

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.340
Threshold uncertainty score0.935

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.268
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations42
Published2024
Admission routes1
Has abstractno

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