CKD-Associated Pruritus: Prevalence and Association with Quality of Life for Peritoneal Dialysis Patients, International Results from PDOPPS
Bibliographic record
Abstract
Background: Chronic kidney disease associated pruritus (CKD-aP) is associated with morbidity. The prevalence and burden of CKD-aP in peritoneal dialysis (PD) is not well-known. We sought to determine the CKD-aP prevalence, identify factors associated with a high severity of CKD-aP and the impact of CKD-aP on quality of life (QOL) among patients in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). Methods: We analyzed cross-sectional data on QOL and CKD-aP from PDOPPS patients from Australia, Canada, Japan, New Zealand, Republic of South Korea, Thailand, the UK, and US between 2014-22. CKD-aP severity in the preceding 4 weeks was self-rated by patients using a 5-point Likert scale from 1: “Not at all bothered by itch” to 5: “Extremely bothered by itch”. Factors associated with CKD-aP 3-5 (moderate to extreme) v. 1-2 were analyzed using logistic regression. Adjusted linear regressions were used to compare CKD-aP and QOL, assessed using the physical and mental component summary scores (PCS and MCS) of the 12-item Short-Form (SF-12) on the same questionnaire. Results: 43% of the 5534 patients reported moderate to extreme itch; ranging from 50% and 49% (Thailand and the UK, respectively), to 32% (the US). Adjusted logistic regression revealed several parameters associated with CKD-aP (Figure 1). MCS and PCS were negatively associated with increasing CKD-aP severity (p < 0.0001). Conclusions: Worldwide, CKD-aP is highly prevalent among PD patients and associated with poor quality of life. Efforts to better identify and manage CKD-aP for PD patients are urgently needed. Funding: Other NIH Support - Agency for Healthcare Research and Quality (AHRQ), Commercial Support - Amgen Inc (since 1996, founding sponsor) Akebia Therapeutics, Inc. Astellas Pharma Inc. Bard Peripheral Vascular, Inc. Baxter Healthcare Corp Bayer AG & Bayer Yakuhin, Ltd. Cara Therapeutics, Inc. Chugai Pharmaceutical Co., Ltd. GlaxoSmithKline LLC Japanese Society for Peritoneal Dialysis (JSPD) JMS Co., Ltd. Kidney Foundation Japan (KFJ) Kissei Pharmaceutical Co., Ltd. Kyowa Kirin Co., Ltd. (since 1999 for Japan DOPPS) Merck Sharp & Dohme Corp Nikkiso Co., Ltd. ONO Pharmaceutical Co., Ltd. Terumo Corporation Torii Pharmaceutical Co., Ltd. CSL-Vifor, Ltd., Government Support - Non-U.S.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".