Neuroprotective Effect of <i>Grewia carpinifolia</i> Extract against Behavioral Impairments Induced by Vanadium
Bibliographic record
Abstract
Vanadium is a heavy metal that has been reported to cause toxicity in the central nervous system resulting in various behavioral alterations. This is characterized by the generation of reactive oxygen species. The present study was designed to investigate the probability of Grewia carpinifolia ethanol extract in preventing behavioral impairments following acute vanadium toxicity in mice. Twenty five Swiss albino mice (25–27g) were randomized into 5 groups (A–E) of 5 animals each. Group A received distilled water and served as a control; group B received vitamin E (500mg·kg −1 b.w. every 72 hours), a known antioxidant orally along with a daily dose of sodium metavanadate intraperitoneally (i.p.) for 7 days; group C and group D received Grewia carpinifolia leaf extract at 100 and 200mg·kg −1 b.w orally respectively, along with the sodium metavanadate i.p. for 7 days; while group E received sodium metavanadate i.p. only for 7 days. The behavioral and motor functions were analyzed by the open field, negative geotaxis, and hanging wire tests; the daily body and brain weights were recorded. Grewia carpinifolia ethanol extracts significantly reduced the number of grooming, stretched attend posture, and freezing time that were significantly increased in the vanadium only group and also enhanced the vestibular functions. Furthermore, the latent time spent on the hanging wire in groups simultaneously administered with the extract and vanadium compared positively (P>0.05) with the control groups but a decrease in latent time was observed in the vanadium only group. The results suggest that acute vanadium toxicity results in various behavioral impairments and support a possible role of Grewia carpinifolia as a protective agent against acute vanadium-toxicity with a better result at 200mg·kg −1 b.w. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".