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Record W4398255666 · doi:10.1017/cjn.2024.267

Health Canada Drug Approval Process: A Barrier to Personalized Care in Multiple Sclerosis

2024· article· en· W4398255666 on OpenAlexafffundvenueabout
Jiwon Oh, Virender Bhan, Anthony Traboulsee, Sarah A. Morrow, Liesly Lee, Michael C. Levin, Courtney Casserly, Mark S. Freedman, Paul S. Giacomini, François Émond, Penelope Smyth, Fraser Clift, Daniel Selchen

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2024
Typearticle
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsUniversity of AlbertaMemorial University of NewfoundlandMontreal Neurological Institute and HospitalHealth Sciences CentreOttawa HospitalLondon Health Sciences CentreUniversité LavalUniversity of SaskatchewanSt. Michael's HospitalSunnybrook Health Science CentreHotchkiss Brain InstituteUniversity of British ColumbiaUniversity of Calgary
FundersEMD SeronoUniversity of TorontoSaskatchewan Health Research FoundationHorizon TherapeuticsAtara BiotherapeuticsCelgeneBiogenSaskatoon City Hospital FoundationAlexion PharmaceuticalsTeva Pharmaceutical IndustriesBayer HealthCareSanofiAmgenPfizerOntario Medical AssociationAstraZenecaEli Lilly and CompanyBristol-Myers Squibb
KeywordsMultiple sclerosisExpanded accessDrugProcess (computing)MedicineInternet privacyComputer sciencePharmacologyOncologyPsychiatry

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.050
metaresearch head score (Gemma)0.240
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.937
Threshold uncertainty score0.458

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0500.240
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.005
Science and technology studies0.0070.003
Scholarly communication0.0100.003
Open science0.0030.003
Research integrity0.0060.010
Insufficient payload (model declined to judge)0.0250.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.227
GPT teacher head0.364
Teacher spread0.136 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes4
Has abstractyes

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