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Record W4398318642 · doi:10.1021/acs.organomet.4c00026

Metathesis and Metallacycle Reactivity of d<sup>10</sup> Ni Perfluorocarbenes with Alkenes

2024· article· en· W4398318642 on OpenAlexafffund
Alex L. Daniels, Behnaz Ghaffari, Deqing Kong, Jia Guan, Michael B. Hall, R. Tom Baker

Bibliographic record

VenueOrganometallics · 2024
Typearticle
Languageen
FieldChemistry
TopicSynthetic Organic Chemistry Methods
Canadian institutionsUniversity of Ottawa
FundersNatural Science Foundation of Zhejiang ProvinceDivision of ChemistryNatural Sciences and Engineering Research Council of CanadaMitacsCanada Research ChairsArkemaWelch Foundation
KeywordsMetallacycleChemistryReactivity (psychology)MetathesisMedicinal chemistryStereochemistryOrganic chemistryX-ray crystallographyPhysics

Abstract

fetched live from OpenAlex

We showed previously that the d 10 nickel perfluorocarbene complex, P 3 Ni═CF(CF 3 ) [P = P(O i Pr) 3 ], 1, reacts with fluoroalkenes to produce both 4-membered nickelacycles and metathesis products via separate reaction pathways. Herein, we compare the reactivity of 1 with a variety of alkenes. The reaction of 1 with hexafluoropropene [CF 2 ═CF(CF 3 ), HFP] affords a single metallacycle, taking advantage of the diradical mechanism in which the carbene carbon adds to the CF 2 end of HFP. In contrast, 1 and perfluoro(methyl vinyl ether), CF 2 ═CF(OCF 3 ), yield both metallacycle and metathesis products, with preferential formation of the more stabilized difluorocarbene [P 3 Ni═CF 2 vs P 3 Ni═CF(OCF 3 )] and a higher ratio of metathesis to metallacycle products than using tetrafluoroethylene or vinylidene difluoride. Attempts to form fluoropolymers via ring-opening metathesis polymerization of perfluorocyclobutene and hexafluorocyclopentene briefly gave new nickel carbenes but then yielded Ni fluoroalkene complexes with the loss of the CF(CF 3 ) unit. Surprisingly, both ethylene and styrene derivatives gave only metallacycles, although evidence was obtained for alkene coordination to nickel; computational studies are presented to identify the origin of these observations. Finally, insertion of ethylene into the ethylene-derived nickelacyclobutane afforded a new fluorinated alkene, CH 2 ═CHCH 2 CH 2 CHFCF 3, formed presumably via nickelacyclohexane through selective β-H and reductive eliminations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.038
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0070.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.244
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2024
Admission routes2
Has abstractyes

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