¬3-session vs 5-session dose-fractionation of stereotactic radiosurgery in Glomus Jugulare: Protocol for a Randomized Clinical Trial (Preprint)
Bibliographic record
Abstract
Background: Gamma Knife stereotactic radiosurgery (SRS) is a pivotal therapeutic strategy for managing jugular paragangliomas (JP) due to the tumor's vascularity and the intricacies of regional anatomy.Noteworthy is the comparison between limited-session dose fractionation SRS and multisession fractionated Gamma Knife SRS, with the former being linked to a higher incidence of adverse effects on at-risk organs and the latter may be accompanied by lower rate of tumor control.Objective: The primary objective is to assess tumor size post-intervention, evaluated through MRI sequences at 6-month and 1-year intervals.Secondary objectives include alleviating tumor-associated symptoms, and documenting severe adverse outcomes.Methods: This document outlines a trial protocol for a comparative study evaluating the efficacy of 3-session versus 5-session fractionation in Gamma Knife SRS for JP.In this single-center prospective randomized clinical trial, 40 eligible JP patients will be randomly assigned to receive either three sessions of Gamma Knife SRS (cumulative radiation dose: 18-21 GY) or five sessions (cumulative radiation dose: 21-25 GY).Results: As of March 2024, the patient screening process has not begun, and no participants have been enrolled in the trial. Conclusions:Prior research reveals a significant gap in knowledge, hindering a comprehensive comparison of gamma knife radiosurgery dosage fractionations in JP.This protocol seeks to address this gap by investigating the impact of 3 sessions versus 5 sessions of dose-fractionated Gamma Knife SRS on JP.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Protocol About the Canadian research system: no · About a Canadian topic: no | Randomized trial | low |
| gpt | no category Domain: not available · Genre: Protocol About the Canadian research system: no · About a Canadian topic: no | Randomized trial | high |
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.025 | 0.028 |
| Meta-epidemiology (narrow) | 0.005 | 0.002 |
| Meta-epidemiology (broad) | 0.007 | 0.004 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.003 | 0.003 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.007 | 0.006 |
| Insufficient payload (model declined to judge) | 0.058 | 0.015 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".