¬3-session vs 5-session dose-fractionation of stereotactic radiosurgery in Glomus Jugulare: Protocol for a Randomized Clinical Trial (Preprint)
Bibliographic record
Abstract
Background: Gamma Knife stereotactic radiosurgery (SRS) is a pivotal therapeutic strategy for managing jugular paragangliomas (JP) due to the tumor's vascularity and the intricacies of regional anatomy.Noteworthy is the comparison between limited-session dose fractionation SRS and multisession fractionated Gamma Knife SRS, with the former being linked to a higher incidence of adverse effects on at-risk organs and the latter may be accompanied by lower rate of tumor control.Objective: The primary objective is to assess tumor size post-intervention, evaluated through MRI sequences at 6-month and 1-year intervals.Secondary objectives include alleviating tumor-associated symptoms, and documenting severe adverse outcomes.Methods: This document outlines a trial protocol for a comparative study evaluating the efficacy of 3-session versus 5-session fractionation in Gamma Knife SRS for JP.In this single-center prospective randomized clinical trial, 40 eligible JP patients will be randomly assigned to receive either three sessions of Gamma Knife SRS (cumulative radiation dose: 18-21 GY) or five sessions (cumulative radiation dose: 21-25 GY).Results: As of March 2024, the patient screening process has not begun, and no participants have been enrolled in the trial. Conclusions:Prior research reveals a significant gap in knowledge, hindering a comprehensive comparison of gamma knife radiosurgery dosage fractionations in JP.This protocol seeks to address this gap by investigating the impact of 3 sessions versus 5 sessions of dose-fractionated Gamma Knife SRS on JP.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Protocol About the Canadian research system: no · About a Canadian topic: no | Randomized trial | low |
| gpt | no category Domain: not available · Genre: Protocol About the Canadian research system: no · About a Canadian topic: no | Randomized trial | high |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.017 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".