AB021. SOH24AB_125. Outcomes of children with intestinal failure secondary to gastrointestinal dysmotility
Bibliographic record
Abstract
Background: The primary objective of our study is to determine the characteristics and outcomes of pediatric patients with intestinal failure (IF) secondary to dysmotility. Methods: This is a retrospective cohort study of all patients managed by a multidisciplinary intestinal rehabilitation program with a diagnosis of IF with gastrointestinal (GI) dysmotility between January 1, 2006 and December 31, 2020 with a minimum one year follow up. Student’s t-test, Wilcoxon rank sum test, and X2 were used where appropriate. Results: Fifty-one patients with intestinal dysmotility [median gestational age of 35 weeks, interquartile range (IQR): 31–37 weeks; 22 males (43%)] were studied. Median birthweight was 2,160 g (IQR: 1,635–2,586 g). Eighty-eight percent achieved enteral autonomy (EA) after a median parenteral nutrition duration of 150.5 days (IQR: 93.0–206.0 days). Advanced liver disease [conjugated bilirubin (cBili) >100 μmol/L] was seen in 2/51 patients (3.9%), with no patients receiving an intestinal or liver transplant. The case fatality rate was 3/51 (5.9%) but was related to complications of prematurity. Median follow up was 747 days (IQR: 420.5–1,691.5 days). Patients with a congenital short bowel syndrome (SBS) diagnosis (i.e., gastroschisis, necrotizing enterocolitis) had an earlier referral age [75 (IQR: 48–109) vs. 868 (IQR: 61–1,286) days] and were more likely to achieve EA (97% vs. 64%, P<0.01) compared to those with primary dysmotility (i.e., chronic intestinal pseudo-obstruction). Conclusions: This cohort study demonstrates significant long-term survival for patients with dysmotility. There were two distinct populations-neonates with a congenital SBS diagnosis and those presenting later with a primary dysmotility. Patients with a congenital diagnosis had transient symptoms and were likely to achieve EA by 6 months.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".