AB159. SOH24AB_033. Outcomes following spinal surgery in patients with Parkinson’s disease: a systematic review and meta-analysis
Bibliographic record
Abstract
Background: Parkinson’s disease (PD) patients represent challenging spinal surgery candidates due to associated deformity. This study consolidates the literature concerning spinal surgery outcomes in PD versus non-PD patients, to evaluate if PD predisposes patients to worse post-operative outcomes, so that treatment protocols can be optimised. Methods: A systematic review and meta-analysis was conducted of PubMed/Medline, Embase, and Google Scholar databases per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies of interest included comparative (PD vs. non-PD) cohorts undergoing spinal surgery. Post-operative clinical outcomes were collated and compared for significance between cohorts. All statistical analysis was performed using The R Project for Statistical Computing (version 4.1.2), with a P value of P<0.05 deemed statistically significant. Results: In total, 494,049 patients were included across the 7 studies. Of those, 485,374 (98.2%) were patients without PD (non-PD), while 8,675 (1.8%) patients had PD at time of surgery. The collective mean age was noted as 69.9 years (PD: 70.9 years vs. non-PD: 68.5 years). Comparatively, there were 209,761 males (PD: 4,526; non-PD: 205185) and 284,288 females (PD: 4,147; non-PD: 279,976). Overall, there were more post-operative complications in the PD cohort (P=0.02). PD-patients experienced more mechanical complications (P=0.03), surgical site infections (P<0.01), and trended towards increased rates of post-operative delirium (P=0.06) and revision surgeries (P=0.09). No difference existed between cohorts for mortality (P=0.42). Conclusions: Although more robust prospective studies are needed, the results of this study highlight the need for advanced wound care management in the postoperative period, both in-hospital and in the community, in addition to comprehensive multidisciplinary care from allied health professionals, with potential for the use of enhanced recovery after surgery (ERAS) protocols in PD-patients undergoing spine surgery.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.011 | 0.004 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".