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Record W4399300859 · doi:10.1016/s0140-6736(24)00885-7

Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

2024· article· en· W4399300859 on OpenAlex
Hans Gelderblom, Vivek A. Bhadri, Silvia Stacchiotti, Sebastian Bauer, Andrew J. Wagner, Michiel A. J. van de Sande, Nicholas M. Bernthal, Antonio López–Pousa, Albiruni Abdul Razak, Antoîne Italiano, Mahbubl Ahmed, Axel Le Cesne, Gabriel Tinoco, Kjetil Boye, Javier Martín‐Broto, Emanuela Palmerini, Salvatore Tafuto, Sarah Pratap, Benjamin Powers, Peter Reichardt, Antonio Casado, Piotr Rutkowski, Christopher Tait, Fiona Zarins, B. Harrow, Maitreyi G. Sharma, Rodrigo Ruiz‐Soto, Matthew L. Sherman, Jean‐Yves Blay, William D. Tap, Herbert H. Loong, Antonella Brunello, Andreas H. Krieg, Mark Algulnik, Richard F. Riedel, Scott H. Okuno, Elizabeth T. Loggers, Thierry Alcindor, Virginia Ferraresi, César Serrano, R. Lor Randall, Breelyn A. Wilky, Vinod Ravi

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueThe Lancet · 2024
Typearticle
Languageen
FieldMedicine
TopicMusculoskeletal synovial abnormalities and treatments
Canadian institutionsPrincess Margaret Cancer Centre
FundersDaiichi Sankyo EuropeFoghorn TherapeuticsServierNational Cancer InstituteChugai PharmaceuticalGenentechEuropean Network for Rare Adult Solid CancersIpsenPharmaMarEuropean Society for Medical OncologyAstraZenecaInstitut National Du CancerPfizerSymphogenIncyteAmgenDeciphera PharmaceuticalsConnective Tissue Oncology SocietyKaryopharm TherapeuticsBristol-Myers SquibbEli Lilly and CompanyIterion TherapeuticsSanofiLes Laboratories Pierre Fabre
KeywordsMedicinePlaceboClinical endpointPopulationSurgeryClinical trialInternal medicineAdverse effectPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.066
Threshold uncertainty score0.906

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.348
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it