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Record W4399440871 · doi:10.14283/jpad.2024.109

Performance of a Short Version of the Everyday Cognition Scale (ECog-12) to Detect Cognitive Impairment

2024· article· en· W4399440871 on OpenAlexfundno aff
Manchumad Manjavong, A Diaz, Miriam T. Ashford, Anna Aaronson, Melanie J. Miller, Jaemyeong Kang, Sharon Mackin, R Tank, Bernard Landavazo, Diana Truran, S T Farias, Michael W. Weiner, Rachel L. Nosheny

Bibliographic record

VenueThe Journal of Prevention of Alzheimer s Disease · 2024
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
FundersNational Institute on AgingCanadian Institutes of Health ResearchNational Institutes of HealthNestecLarry L. Hillblom FoundationGenentechIXICOServierEisaiU.S. Department of DefenseEli Lilly and CompanyAustralian Catholic UniversityNorthern California Institute for Research and EducationPfizerBioClinicaBiogenNovartis Pharmaceuticals CorporationH. Lundbeck A/SNational Institute of Mental HealthPatient-Centered Outcomes Research InstituteBristol-Myers SquibbAlzheimer's Disease Neuroimaging InitiativeMeso Scale DiagnosticsCalifornia Department of Public HealthAlzheimer's AssociationFoundation for the National Institutes of Health
KeywordsCognitionCognitive impairmentScale (ratio)PsychologyCognitive psychologyNeuroscienceCartographyGeography

Abstract

fetched live from OpenAlex

BACKGROUND: The Everyday Cognition (ECog) 12-item scale, a functional decline measurement, can distinguish dementia from cognitively unimpaired (CU). Limited data compare ECog-12 performance by raters (self vs. informant) and scoring systems (average numeric vs. categorical grouping) to differentiate cognitive statuses. OBJECTIVES: To evaluate the performance of ECog-12 in differentiation cognitive statuses. DESIGN: A cross-sectional diagnostic test study. SETTING AND PARTICIPANTS: Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study are analyzed. Participants were aged 55-90 years old divided into subgroups based on diagnostic criteria. MEASUREMENTS: We evaluated ECog-12 performance across different diagnostic groups, such as CU vs cognitive impairment (CI; mild cognitive impairment (MCI), and dementia), and the association between ECog-12 and CI. This procedure was repeated for self- and partner (informant)-reports. Additionally, types of ECog scores were also assessed, where an average ECog score was calculated (continuous numeric) as well as a categorical grouping ("any occasional declined" or "any consistently declined") based on item-level responses to ECog questions. RESULTS: ECog-12 cut-off scores of 1.36 (self-reported) and 1.45 (partner-reported) distinguish CU from CI with AUC 0.7 and 0.78, respectively. Adding a memory-concern question improved self-reported-ECog AUC to 0.79. Self- and partner-reported "consistently-declined" ECog-12 categorical grouping provided AUC 0.69 and 0.78. The study partner reported ECog-12 showed a greater association with CI than self-reported, with odds ratios of 35.45 and 8.79, respectively. CONCLUSION: Study partner-reported ECog scores performed better than self-reported ECog-12 in differentiating cognitive statuses, and a higher study partner reported ECog score was a higher prognostic risk for CI. A memory concern question could enhance self-reported ECog-12 performance. This further emphasizes the need to obtain data from study partners for research and clinical practice.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.460
Threshold uncertainty score0.525

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.321
Teacher spread0.300 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2024
Admission routes1
Has abstractyes

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