RETRACTED ARTICLE: Novel Cadmium Telluride Quantum Dot (QD) Fluorescent Probe for the Sensitive Determination of the Hepatocellular Carcinoma (HCC) Biomarker Alpha-Fetoprotein (AFP)
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Abstract
The concentration of alpha-fetoprotein (AFP) generally increases in the serum of hepatocellular carcinoma (HCC) patients. Hence, AFP is a biomarker for HCC detection, diagnosis, and treatment. However, the sensitivity is unsatisfactory. Here a fluorescent probe based on CdTe quantum dots (QDs-AFPAb) was prepared and a simple sensitive fluorescence immunoassay on nitrocellulose membranes (NFIA) was developed for alpha-fetoprotein. This method exhibited a low detection limit of 2.18 pg/mL with a linear range from 10 to 1.0 × 107 pg/mL. In addition, the sensitivity allowed the identification of HCC and non-HCC serum. This method is sensitive, easy, and low-cost for the diagnosis of HCC.
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The record
- Venue
- Analytical Letters
- Topic
- Nanoplatforms for cancer theranostics
- Field
- Engineering
- Canadian institutions
- IONICS Mass Spectrometry (Canada)
- Funders
- K. C. Wong Magna Fund in Ningbo UniversityNatural Science Foundation of NingboZhejiang Key Laboratory of Pathophysiology
- Keywords
- ChemistryHepatocellular carcinomaQuantum dotAlpha-fetoproteinFluorescenceBiomarkerCadmiumCadmium telluride photovoltaicsCancer researchNanotechnologyBiochemistryOptics
- Has abstract in OpenAlex
- yes