Pain relief in cervical dystonia following regular long-term botulinum therapy
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Introduction. Cervical dystonia (CD) is characterized by pain, which is often the main reason for visiting a doctor. Analgesics are often used to control pain, but regular administration of botulinum toxin type A (BTA) may be more effective. The effectiveness of regular long-term use of BTA in CD in relation to pain has been little studied, which served as the basis for this study. Material and methods. For 3 years, 65 patients (44 men, 21 women, average age 53±15 years) with CD who regularly received BTA therapy were observed. The severity of CD was assessed using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), pain — using TWSTRS and a Numeric Rating Scale (NRS) at baseline, one month after BTA therapy and 3 years later during the period of maximum severity of symptoms (before the next BTA injection). Results. A decrease in pain according to NRS and TWSTRS was shown not only after 1 month, but also after 3 years (p<0.0001). The reduction in pain was significant for initially moderate and severe pain according to the NRS of pain (p<0.0001). In patients with mild pain intensity, no significant changes were noted (F=1.5, p=0.23). An inverse correlation was noted between the sensory trick and the duration of the disease. Conclusion. The use of BTA for CD reduces pain not only after a month, but also after 3 years of regular therapy during the period of maximum severity of symptoms.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it