Perioperative Care of a Child With Allan-Herndon-Dudley Syndrome
Bibliographic record
Abstract
Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder resulting from mutation of the SLC16A2 gene leading to a deficiency of a the monocarboxylate transporter 8 (MCT8) protein, which facilitates the passage of triiodothyronine (T3) into the central nervous system (CNS). Central lack of T3 leads to increased production of thyroid-stimulating hormone (TSH) with peripheral overproduction of thyroid hormones and systemic signs and symptoms of hyperthyroidism, as well as severe CNS effects including neurodevelopment delay, intellectual disability, hypotonia, and failure to thrive. We present a 6-year-old child with AHDS who required multiple anesthetics for various procedures, including right open adductor tenotomy, right proximal femoral varus osteotomy, and right acetabular osteotomy. The basic cellular defect of AHDS is described, end-organ effects outlined, and impact on perioperative care reviewed. Int J Clin Pediatr. 2024;13(2):48-53 doi: https://doi.org/10.14740/ijcp535
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".