Investigating the Impact of C. krusei and Chitosan Treatment on Liver and Kidney Function: A Comprehensive Study
Bibliographic record
Abstract
The present research explores the effects of Candida krusei yeast infection and chitosan treatment on rabbit liver and kidney functions.Utilizing male rabbits as a model, the research categorizes them into four distinct groups for clarity: the Candida krusei Infection Group, the Chitosan Treatment Group, the Combined C. krusei and Chitosan Group, and the Control Group.It was found that the C. krusei Infection Group and the Combined C. krusei and Chitosan Group had a significant increase in blood serum glucose levels as compared to the Control Group (P < 0.05).Comparatively, the Chitosan Treatment Group exhibited a significant reduction in glucose levels indicating a neutralizing impact on the hyperglycemia caused by C. krusei.The other finding is that the Group in the Chitosan Treatment 4 demonstrated significantly reduced levels of urea and uric acid in the blood serum than in the Group in the Control, which reflects a likely protection of kidney function (P < 0.05).In relation to protein metabolism, the Chitosan Treatment Group presented an elevation in total plasma protein levels and a reduction in serum albumin concentrations with significant differences (P < 0.05) when compared to the Control Group.The globulin levels analysis, in turn, confirmed these results, displaying a close tendency.Liver tissue sections histological examination reported that a hemorrhage within the parenchyma and hemolysis in the Chitosan Treatment Group, the C. krusei, and Nystatin Treated Groups showed inflammatory infiltrates, and extensive steatosis.The steatosis and lymphocytes infiltration were found in C. krusei Infection Group, in turn the focal lymphocytic infiltration and some necrotic cells were observed in Combined C. krusei and Chitosan Group.Kidney tissues in the Chitosan Treatment Group exhibited glomerular atrophy, while those of the C. krusei and Nystatin-Treated Groups showed lymphocyte infiltration and renal tubule dilation.The C. krusei Infection Group presented with renal tubule laceration and endothelial cell degeneration, whereas the Combined C. krusei and Chitosan Group had glomerular prolapse and early atrophy.All in all, in this study, the effects of C. krusei infection and chitosan therapy on glucose metabolisms, renal function and histological integrity of liver and kidney tissues in rabbits were revealed to be contrasting.The chitosan treatment provided resistance to the rabbits against the systemic effects of the C. krusei infection, showing its prophylactic role in both fungal infections and their systemic consequences.This type of knowledge reinforces the chitosan therapy possibility, and at the same time dictates the necessity of more clinical use and safety studies.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".