ANTI-SPERMAL ANTIBODIES AND PERIPHERAL DOPAMINE IN MEN WITH CONSIDERATION OF CONTRAST PHOTOPERIODISM IN THE EUROPEAN NORTH
Bibliographic record
Abstract
The physiological role of reference levels of antispermal antibodies (ASABs) in fertile men and mechanisms controlling their concentration are still not fully understood. It is hypothesized that they may contribute to the immunological tolerance of testicles in healthy organism. We investigated the relation between ASABs and dopamine in blood of different groups of males living in the European North with consideration of contrast photoperiodism. Participants were 20 Caucasian males in Arkhangelsk observed over 4 seasonal photoperiods and 108 male dwellers of local settlements (Caucasians, Nenets, komi and metis aborigines), and aborigines migrating nearby who were observed in the periods of minimal light days (December) and then in March. IFA was used to determine concentrations of ASABs in serum and dopamine in blood. Minimal ASABs and increasing dopamine were determined in Archangelsk in the period of maximal daylight hours and in the Caucasian males in settlements in the period of light time which can serve as an argument for specifying periods most favorable for conception. Males in settlements and migrants were distinguished by a higher ASABs level in comparison to the male population in Archangelsk in December against dopamine imbalance due to, probably, oxidative stress and increased permeability of the blood-testis barrier. This finding calls for a close attention to the reproductive system condition. Elevated ASABs levels were observed on the backgrounds of undetectable (0 nmol/l) and abnormal (>0.653 nmol/l) dopamine values, whereas decreased ASABs concentrations were found with dopamine at reference levels. Based on these results of the investigation we assume a dose-dependent dopamine effect on ASABs and propose a hypothesis that control of dopamine in blood could prevent autoimmune sterility.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".