Moving the needle on proteasome inhibitor-induced pulmonary arterial hypertension: a definite maybe
Bibliographic record
Abstract
Extract Drug- or toxin-induced pulmonary arterial hypertension (DPAH) is a rare form of group 1 pulmonary arterial hypertension (PAH). In the current PAH classification, the association between drugs or toxins and PAH can either be categorised as “definite” or “possible”, with definite associations requiring data from outbreaks, epidemiological case–control studies, and/or large multicentre cohort studies. Conversely, possible associations are identified through multiple case series or by drugs with similar mechanisms of action [1]. Based on these criteria, the proteasome inhibitors – a class of medication that disrupts normal protein degradation, commonly used in the treatment of multiple myeloma [2] – are currently categorised as having a “possible association” with PAH. Historically, establishing a strong causal link between the initiation of a drug or toxin and the development of PAH has been difficult, and complicated by various factors, including the lack of supportive pharmacodynamic and/or pharmacogenomic studies, variable latency periods between drug initiation and the development of PAH, unpredictable response to drug/toxin withdrawal and/or rechallenge, and confounding by indication, comorbidities and/or concurrent medications [3].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.018 |
| Meta-epidemiology (narrow) | 0.004 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.002 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.003 | 0.003 |
| Scholarly communication | 0.006 | 0.007 |
| Open science | 0.004 | 0.001 |
| Research integrity | 0.015 | 0.021 |
| Insufficient payload (model declined to judge) | 0.012 | 0.012 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".