P142 Symptomatic improvement within 2 days of etrasimod induction therapy for ulcerative colitis in ELEVATE UC 52 and ELEVATE UC 12
Bibliographic record
Abstract
Introduction Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis. This post hoc analysis assessed improvement in rectal bleeding (RB) and stool frequency (SF) in patients (pts) in ELEVATE UC 52 (NCT03945188) and ELEVATE UC 12 (NCT03996369). Methods Daily e-diary data on RB and SF were pooled. Daily Mayo RB and SF subscores (RBS and SFS) and partial modified Mayo score (pMMS; RBS+SFS), and change from baseline (CFB) in the first 28 days of therapy, were calculated. Symptomatic response and remission, and RB and SF remission are reported. Results At baseline, pts receiving etrasimod 2 mg QD and placebo (PBO) had mean (SD) RBS 1.6 (0.69) and 1.6 (0.68), SFS 2.4 (0.74) and 2.4 (0.74), and pMMS 4.0 (1.07) and 4.0 (1.07), respectively. Adjusted differences (etrasimod vs PBO) became significant from Day 2 and 11 for symptomatic response and remission, and Day 15 and 3 for RB and SF remission, respectively (all p<0.05; table 1 Daily responses in pts receiving etrasimod vs PBO on the first day of a significant adjusted difference in response). Conclusions Significant, early improvements indicate a potentially rapid onset of symptomatic effect in pts receiving etrasimod.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".