P142 Symptomatic improvement within 2 days of etrasimod induction therapy for ulcerative colitis in ELEVATE UC 52 and ELEVATE UC 12
Bibliographic record
Abstract
<h3>Introduction</h3> Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P)<sub>1,4,5</sub> receptor modulator for the treatment of moderately to severely active ulcerative colitis. This post hoc analysis assessed improvement in rectal bleeding (RB) and stool frequency (SF) in patients (pts) in ELEVATE UC 52 (NCT03945188) and ELEVATE UC 12 (NCT03996369). <h3>Methods</h3> Daily e-diary data on RB and SF were pooled. Daily Mayo RB and SF subscores (RBS and SFS) and partial modified Mayo score (pMMS; RBS+SFS), and change from baseline (CFB) in the first 28 days of therapy, were calculated. Symptomatic response and remission, and RB and SF remission are reported. <h3>Results</h3> At baseline, pts receiving etrasimod 2 mg QD and placebo (PBO) had mean (SD) RBS 1.6 (0.69) and 1.6 (0.68), SFS 2.4 (0.74) and 2.4 (0.74), and pMMS 4.0 (1.07) and 4.0 (1.07), respectively. Adjusted differences (etrasimod vs PBO) became significant from Day 2 and 11 for symptomatic response and remission, and Day 15 and 3 for RB and SF remission, respectively (all <i>p</i><0.05; table 1 Daily responses in pts receiving etrasimod vs PBO on the first day of a significant adjusted difference in response). <h3>Conclusions</h3> Significant, early improvements indicate a potentially rapid onset of symptomatic effect in pts receiving etrasimod.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".