P113 Maintenance of week 12 response through week 52 with etrasimod in patients with ulcerative colitis in ELEVATE UC 52
Why this work is in the frame
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Bibliographic record
Abstract
<h3>Introduction</h3> Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P)<sub>1,4,5</sub> receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). This post hoc analysis evaluated efficacy at Week 52 in ELEVATE UC 52 (NCT03945188) among patients who met efficacy endpoints at the end of induction (Week 12). <h3>Methods</h3> Patients (16–80 years) with modified Mayo Score 4–9, endoscopic subscore (ES) ≥2 and rectal bleeding subscore (RBS) ≥1 were randomised 2:1 to etrasimod 2 mg QD or placebo for 12-weeks’ induction followed by a 40-week maintenance period with treat-through design. The proportions of etrasimod-treated patients that sustained clinical remission, endoscopic improvement, endoscopic improvement-histologic remission (EIHR), symptomatic remission and RBS=0 at Week 52 were evaluated among Week 12 responders for those endpoints. <h3>Results</h3> Among the 289 etrasimod-treated patients, at Week 12, 28.0% (81/289) achieved clinical remission, 37.4% (108/289) endoscopic improvement, 22.8% (66/289) EIHR, 46.4% (134/289) symptomatic remission and 57.4% (166/289) RBS=0. Among the Week 12 responders, the proportion who sustained response at Week 52 was high and ranged from 63.6% for EIHR to 75.3% for RBS=0 (table 1 Etrasimod-treated patients who sustained Week 12 responses at Week 52). <h3>Conclusions</h3> Etrasimod-treated patients who achieved Week 12 efficacy endpoints were very likely to maintain clinical, endoscopic and histologic efficacy responses at Week 52.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it