Inhibitory Effect of Herb Extract-Amino Acid Mixtures on UV-Induced Photoaging in HaCaT Cell
Bibliographic record
Abstract
This study examined the optimal ratio of herb extract to amino acids, effectively protecting skin cells from UVB-induced photoaging.The response surface methodology program suggested seven mixture ratios of herb extracts, including ginger and star anise extracts.Among them, the H7 mixture showed the highest antioxidant activity.Arginine and glutamate were added to H7, producing HA1, HA2, and HA3 mixtures to determine their effects on UV-induced photoaging.The HA3 mixture had the highest protective effect against UV-induced cell death.HA3 significantly increased the mRNA expression of collagen 1, hyaluronic acid, and matrix metalloproteinase (1/2) while reducing the activity of hyaluronic acid lyase.HA3 significantly increased the expression of skin barrier genes, including filaggrin, loricrin, and involucrin.Overall, the HA3 mixture effectively protects skin cells from UV-induced photodamage.This study suggested an optimized herb extract/amino acid mixture ratio for developing skin-protective functional foods.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".