Condyloma Lata: A Vulvar Manifestation of Secondary Syphilis
Bibliographic record
Abstract
In the initial decades of the 21st century, a rise in the incidence of syphilis has been observed in all developed countries. This disease has become not only a public health concern, but also a problem in clinical practice, since clinicians need to have sufficient knowledge and experience for an early diagnosis and treatment. Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum . In secondary syphilis, condyloma lata, a papular lesion typical of this stage of the disease, has been reported in 6% to 23% of patients. Here we present two cases of patients diagnosed with secondary syphilis, who presented condyloma lata on the vulvar area as the first clinical manifestation. Biopsy of lesions and observation with dark-field microscopy revealed abundant spirochetes. It was not an easy diagnosis either for the clinician and the pathologist as it can be similar to other dermatological conditions, such as anogenital warts (condyloma acuminata). Patients were treated with penicillin until complete resolution of the clinical signs. Secondary syphilis is currently uncommon in developed countries, especially with condyloma lata as the first clinical manifestation. J Clin Gynecol Obstet. 2024;13(2):41-47 doi: https://doi.org/10.14740/jcgo960
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".