Influence of the liquid ionic strength on the resonance frequency and estimated shell parameters of lipid-coated microbubbles
Bibliographic record
Abstract
Measurement of the resonance frequency and shell properties of coated microbubbles (MBs) is important in understanding and optimizing their response to ultrasound. In many applications MBs are in ionic liquids; however, the influence of the medium charges on the MB behavior is not well investigated. This study aims to measure the medium charge interactions with MBs by measuring the frequency-dependent attenuation of the same size MBs in mediums of varying charge density. In-house lipid-coated MBs were size isolated to a mean size of 2.35 μm using differential centrifugation. MBs were suspended in distilled water (DW), Phosphate-Buffered Saline solution (PBS1×) and PBS10×. The frequency-dependent attenuation of the MBs solutions was measured using a system of two aligned 100% bandwidth transducers with 10 MHz center frequency. The MB shell properties were estimated by fitting the linear equation to experiments. With increasing salinity, the frequency of the peak attenuation decreased (13, 7.5 and 6.25 MHz in DW, PBS1× and PBS-10×, respectively) and attenuation peak increased (∼140%). Estimated MBs shell elasticity decreased by 64% between DW and PBS-1× and 36% between PBS-1x and PBS-10x. The estimated shell viscosity reduced by ∼40% between DW and PBS-1× and 42% between PBS-1× and PBS-10×. The significant reduction in the fitted stiffness and viscosity is possibly due to the formation of a densely charged layer around the shell and requires proper inclusion in the related MB models.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".