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Record W4400869843 · doi:10.1038/s41587-024-02324-x

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

2024· article· en· W4400869843 on OpenAlexfundno aff
Joana Ferreira da Silva, Connor J. Tou, Emily M. King, Madeline L. Eller, David Rufino‐Ramos, Linyuan Ma, Christopher R. Cromwell, Jasna Metović, Friederike M. C. Benning, Luke H. Chao, Florian Eichler, Benjamin P. Kleinstiver

Bibliographic record

VenueNature Biotechnology · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsnot available
FundersNIH Office of the DirectorNational Cancer InstituteNational Center of Competence in Research Quantum Science and TechnologyNational Heart, Lung, and Blood InstituteDana-Farber Cancer InstituteNational Human Genome Research InstituteNational Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesMassachusetts General HospitalNatural Sciences and Engineering Research Council of CanadaFriedreich's Ataxia Research AllianceNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEuropean Molecular Biology OrganizationNational Science Foundation
KeywordsGenome editingDNA polymerasePolymeraseDNAEndonucleaseComputational biologyBiologyGenomeGeneticsComputer scienceGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.134
Threshold uncertainty score0.791

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.286
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations65
Published2024
Admission routes1
Has abstractno

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