PyNeuroTrace - Python code for neural activity timeseries
Bibliographic record
Abstract
Modern techniques for measuring neuronal activity using fluorescent biosensors and ultra-fast microscopy have allowed neuroscientists unprecedented access to neural information processing in vivo.The time series datasets generated from experiments sampling somatic action potentials from populations of neurons, or full-dendritic arbor sampling of populations of synapses, are becoming increasingly larger as new technologies allow for faster acquisition rates and higher temporal resolution of neural signals.Neuronal activities are sourced from an ever-expanding library of fluorescent indicators of distinct measures, including detectors of calcium, membrane voltage, and a range of neurotransmitters and neuromodulators.These biosensors are impacted by their unique molecular kinetics and inherent signal-to-noise properties.The quality of neural signal data sets are also impacted by acquisition instruments, which differ in sensitivity and sampling rate.All of these features, including underlying neural signals, biosensor properties, and microscope capabilities, must be considered during post-imaging signal processing with techniques that can scale to the size of modern neural datasets.To address this problem, here, we describe pyNeuroTrace, an open-source Python library developed to aid in processing neuronal signals from large fluorescent biosensor data sets, which allows dynamic control of filtering and signal processing with these unique aspects in mind before analyses of the underlying neuronal activity can be conducted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.007 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.005 | 0.004 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.080 | 0.046 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".