Cholangioscope-assisted evaluation and endoscopic incision of stricture caused by thick mucosal bridge in Crohn’s disease
Bibliographic record
Abstract
A 32-year-old man with an 8-year history of Crohn’s disease (Montreal classification A2, L3, B2p) presented with recurrent abdominal pain. After regular treatment with ustekinumab for 3 years, recent computed tomography revealed severe stricture in the ascending colon ([ Fig. 1 ]), and colonoscopy showed colorectal mucosal healing. However, two tiny holes were observed and could not be passed by the colonoscope ([ Fig. 2 ]). Fig. 1 Computed tomography showed severe stricture of the ascending colon in Crohn’s disease. Fig. 2 Two tiny holes in the stricture were observed and could not be passed by the colonoscope. In order to find out which hole was the real narrow bowel lumen and to exclude a potential fistula, a cholangioscope (eyeMAX, 9 F; Micro-Tech, Nanjing, China) was inserted into the two holes respectively to gain direct views inside and behind the holes ([ Fig. 3 ]) [ 1 ] [ 2 ]. Amazingly, the ileocecal valve was reached by the cholangioscope through both holes, and superficial ulcer in the inner wall of the holes and multiple scar changes in the ileocecal region were observed simultaneously ([ Fig. 4 ]). The cholangioscopy result indicated that the stricture was caused by a rare thick mucosal bridge between the two holes. Subsequently, the bridge mucosa and submucosal scar were incised by an ITknife nano (Olympus, Tokyo, Japan) ([ Fig. 5 ]). No active bleeding or perforation occurred during the procedure. Finally, the colonoscope could pass smoothly through the stricture and reach the ileocecal valve ([ Video 1 ]). Fig. 3 The cholangioscope was inserted into one hole. Fig. 4 Cholangioscopy showed superficial ulcers in the inner wall of the stricture. The cholangioscope reached the ileocecal valve through both holes. Fig. 5 The stricture was treated after incision of the bridge mucosa and submucosal scar under colonoscopy. Download Video Cholangioscopy-assisted evaluation and targeted treatment for Crohn’s disease-associated stricture.Video 1 Currently, the evaluation of bowel stenosis in Crohn’s disease is mainly based on radiology and ultrasonography [ 3 ]. However, neither method can directly reveal the clear presentation of the inner wall of the narrowed intestinal lumen, including ulcers, tiny fistula, and edema near the stricture. To our knowledge, this is the first reported case of cholangioscope-assisted evaluation and management of Crohn’s disease-related stricture, and suggests the feasibility of the procedure in selected Crohn’s disease cases. Endoscopy_UCTN_Code_TTT_1AQ_2AF Endoscopy E-Videos https://eref.thieme.de/e-videos E-Videos is an open access online section of the journal Endoscopy , reporting on interesting cases and new techniques in gastroenterological endoscopy. All papers include a high-quality video and are published with a Creative Commons CC-BY license. Endoscopy E-Videos qualify for HINARI discounts and waivers and eligibility is automatically checked during the submission process. We grant 100% waivers to articles whose corresponding authors are based in Group A countries and 50% waivers to those who are based in Group B countries as classified by Research4Life (see: https://www.research4life.org/access/eligibility/ ). This section has its own submission website at https://mc.manuscriptcentral.com/e-videos . Publication History Article published online: 16 August 2024 © 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/). Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".