Multiple dynamic modes of Bicoid morphogen gradient are explained by a quantum-classical model
Bibliographic record
Abstract
Extracellular diffusion coupled with degradation is considered a dominant mechanism behind the establishment of morphogen gradients. However, the fundamental nature of these biophysical processes, visa viz, the Bicoid (Bcd) morphogen gradient, remains unclear. Fluorescence correlation spectroscopy has recently revealed multiple modes of Bcd transport at different spatial and temporal locations across the embryo. Here, we show that these observations are best fitted by a model fundamentally based on quantum mechanics. It is thus hypothesized that the transient quantum coherences in collaboration with unitary noise are responsible for the observed dynamics and relaxation to a non-equilibrium steady-state of the Bcd morphogen gradient. Furthermore, simulating the associated probability distribution for the model shows that the observed non-zero concentration of the Bcd molecules in the posterior-most parts of the embryo is a result of non-Gaussian distribution characteristic to quantum evolution. We conclude that with the Bcd gradient being essentially a one-dimensional problem, a simple one-dimensional model suffices for its analysis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".