MétaCan
Menu
Back to cohort
Record W4402190288 · doi:10.1038/s41582-024-01005-2

The influence of MOGAD on diagnosis of multiple sclerosis using MRI

2024· review· en· W4402190288 on OpenAlexfundno aff
Ruth Geraldes, Georgina Arrambide, Brenda Banwell, Àlex Rovira, Rosa Cortese, Hans Lassmann, Silvia Messina, Maria A. Rocca, Patrick Waters, Declan Chard, Claudio Gasperini, Yael Hacohen, Romina Mariano, Friedemann Paul, Gabriele C. DeLuca, Christian Enzinger, Ludwig Kappos, Maria Isabel Leite, Jaume Sastre‐Garriga, Tarek Yousry, Olga Ciccarelli, Massimo Filippi, Frederik Barkhof, Jacqueline Palace

Bibliographic record

VenueNature Reviews Neurology · 2024
Typereview
Languageen
FieldMedicine
TopicMultiple Sclerosis Research Studies
Canadian institutionsnot available
FundersUCB PharmaInstituto de Salud Carlos IIINovo NordiskJanssen PharmaceuticalsSanofi GenzymeNational Institutes of HealthHorizon TherapeuticsMereo BioPharmaIXICOUniversity College London Hospitals NHS Foundation TrustEMD SeronoCelltrionFondation CharcotShionogiChugai PharmaceuticalInnosuisse - Schweizerische Agentur für InnovationsförderungMinistero della SaluteBundesministerium für Bildung und ForschungBayer HealthCareUniversity College LondonMultiple Sclerosis SocietyMultiple Sclerosis Society of CanadaAstraZenecaGenentechUniversity of OxfordInternational Progressive MS AllianceSanofiTG TherapeuticsDeutsche ForschungsgemeinschaftMuscular Dystrophy UKEuropean Committee for Treatment and Research in Multiple SclerosisProthenaArgenxErnest Oppenheimer Memorial TrustGlaxoSmithKlineGuthy-Jackson Charitable FoundationF. Hoffmann-La RocheAlexion PharmaceuticalsMedical Research CouncilBristol-Myers SquibbTeva Pharmaceutical IndustriesEli Lilly and CompanyU.S. Department of DefenseBiogenFondazione Italiana Sclerosi MultiplaCelgeneNational Institute for Health and Care ResearchCSL Behring
KeywordsMedicineMultiple sclerosisMagnetic resonance imagingMedical diagnosisMyelin oligodendrocyte glycoproteinDifferential diagnosisPathologyRadiologyDiseaseOptic neuritisTransverse myelitisImmunologyExperimental autoimmune encephalomyelitis

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.011
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.011
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0040.003
Science and technology studies0.0000.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.163
GPT teacher head0.423
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2024
Admission routes1
Has abstractno

Explore more

Same venueNature Reviews NeurologySame topicMultiple Sclerosis Research StudiesFrench-language works237,207