Effect of a combination of alendronate sodium and radial shock wave on hemorheology and degree of pain in patients with femoral head necrosis
Bibliographic record
Abstract
Purpose: To determine the effect of alendronate sodium combined with radial shock wave on hemorheology and degree of pain in patients with femoral head necrosis. Methods: The study comprised 188 patients with femoral head necrosis treated in Taizhou People’s Hospital, China from June 2020 to June 2022. They were divided into control group (CG, n = 96) and study group (SG, n = 92). Control group was given radial shock wave therapy once in 30 days, while the study group was given alendronate sodium orally (10 mg/daily) for 3 months, as well as radial shock wave therapy. Hemorheology indices (plasma viscosity (PV), low-cut reduced viscosity (LRV), high-cut reduced viscosity (HRV)); degree of pain (McGill Pain Questionnaire (MPQ)), joint muscle strength, and clinical efficacy in both groups were compared. Results: The SG had significantly lower levels of PV, LRV and HRV, and lesser MPQ scores at 1 month (T1) and 2 months post-treatment (T2) than CG (p < 0.05). The post-treatment levels of PV, LRV, HRV, and MPQ scores at T1 stage in the two groups were significantly lower than the pre-treatment (T0) scores (p < 0.001). The scores of PV, LRV, HRV, and MPQ at T2 in both groups were significantly lower than the corresponding T1 scores (p < 0.05). Higher numbers of cases with grade 4 and grade 5 joint muscle strength were seen in SG than in CG at T2. Treatment efficacy/effectiveness in SG was significantly higher than in CG (p < 0.05). Conclusion: Alendronate sodium combination with radial shock wave, produces significant improvement in femoral head necrosis, mitigates symptoms and enhances joint muscle strength of patients. Future studies with larger sample sizes will be necessary to validate the outcome of this study.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".