The effects of a six-month exercise intervention on white matter microstructure in older adults at risk for diabetes
Bibliographic record
Abstract
Older adults with prediabetes or obesity (i.e., those at risk for diabetes) exhibit impaired structural brain networks. Given findings that resistance training (RT) can combat brain impairments in many populations, this study aimed to test the effects of this type of exercise on white matter microstructure in older adults at risk for diabetes. Seventeen community-dwelling older adults (mean age 67.8 ± 5.7, 52.9 % female) with prediabetes or obesity were randomly allocated to thrice weekly RT or balance and tone training (BAT; control group) for six months. Diffusion weighted imaging via a 3T scanner was used to assess changes in white matter parameters -fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) - over time. Participants in the RT group showed no significant changes in FA but had increased MD and RD in various regions related to cognitive function including the cingulate gyrus. Participants in the control group had both increased and decreased FA depending on the specific white matter tracts; increased FA was seen in areas related to motor coordination such as the middle cerebellar peduncle. The control group also exhibited decreased MD and RD in areas responsible for motor function (e.g., left anterior limb of the internal capsule). We conclude that both resistance and balance exercises result in changes in white matter microstructure albeit in divergent tracts that may be linked to the specific exercises performed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".