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Implantable Neural Probe with Thermo-Optic Switches Based on Multimode Interference (MMI) in Thermogenetic Application

2024· article· en· W4402572045 on OpenAlexafffund
Mohammad Makhdoumi Akram, Farshid Shateri, Abdolkhalegh Mohammadi, Alireza Geravand, Wei Shi, Benoit Gosselin

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldNeuroscience
TopicPhotoreceptor and optogenetics research
Canadian institutionsUniversité Laval
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsInterference (communication)Multi-mode optical fiberArtificial neural networkIntegrated opticsComputer scienceElectronic engineeringOptoelectronicsMaterials scienceOptical fiberEngineeringTelecommunicationsArtificial intelligence

Abstract

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This paper presents the design of an implantable neural probe with 8 optical switches that can route the beams in the different brain regions which are sensitive to near-infrared (1550 nm) for thermogenetic applications. The presented probe, which is fabricated in a standard SOI technology, can enable robust activation of neurons using thermosensitive transient receptor potential (TRP) cation channels with a higher spatial and temporal resolution, thanks to the utilization of optical switches and grating couplers with precise spot stimulation. Each optical switch is linked to a waveguide and a grating coupler, enabling simultaneous stimulation of different sites within the brain. The activation or deactivation of optical switches allows controlling passage of light through the desired waveguide to effectively providing optical stimulation to specific neurons or neural circuits. The optical switch works based on the thermo-optics effect that consists of a silicon Multimode Interference (MMI) as an optical splitter and a Titanium nitride (TiN) metal heater that is used for changing the refractive index for π-phase shifting. The measured π-phase shifting power was 19.8 mW with an extinction ratio of 23 dB at 1550 nm. Also, we used a TiN metal as a temperature sensor for controlling the heater. The difference in the temperature sensor impedance was 0.7 Ω when the power was applied to the heater.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.302
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2024
Admission routes2
Has abstractyes

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