ERP biomarkers for go/no-go tasks to detect potential cognitive impairment in community-dwelling older adults
Bibliographic record
Abstract
With an aging population, detecting cognitive dysfunction at an early stage is important. However, no current neurophysiological assessments examine brain activity status in community-dwelling older adults. Therefore, this study aimed to characterize event-related potential (ERP) during go/no-go tasks in older adults with potential cognitive impairment living in the community. The participants were 34 young adults and 46 older adults. They underwent a go/no-go task to measure ERP. The older adults were divided into two groups for analysis based on the results of the Japanese version of the Montreal Cognitive Assessment (MoCA-J): cognitively normal and cognitively impaired. N2 latency was significantly delayed in the cognitively impaired group compared to the cognitively normal and younger groups. Furthermore, the younger group exhibited a significant increase in P3 amplitude and shorter latency compared to both older adult groups. The results of the correlation analysis between ERP and neuropsychological test scores showed that N2 latency correlated with neuropsychological test scores. The results also suggested that receiver operating characteristic curve analysis can measure cognitive function. These results indicated that N2 latency reflected potential cognitive dysfunction in community-dwelling older adults. Furthermore, P3 amplitude may be useful in detecting age-related inhibitory function decline.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".