P125 WORKING LONG HOURS DURING MIDLIFE IS LATER ASSOCIATED WITH INCREASED ARTERIAL STIFFNESS
Bibliographic record
Abstract
Background and Objectives: Arterial stiffness is an asymptomatic cardiovascular disease (CVD) risk marker, resulting from reduced ability of large proximal arteries to dilate and retract. Arterial stiffness is associated with increased CVD, independently of blood pressure (BP). Evidence suggest that tackling modifiable risk factors may alter the pathogenic process leading to CVD, by reducing arterial stiffness progression. Long working hours is a frequent and modifiable risk factor from the work environment, shown to increase the risk of CVD. There is sparse evidence about the effect of long working hours on arterial stiffness. No previous study have used carotid-femoral pulse wave velocity (PWV), recognized as the reference assessment method. This study aims to examine whether long working hours, repeatedly assessed at midlife, is associated with increased arterial stiffness at older age in a 24-year prospective study of white-collar workers in Quebec City, Canada. Methods: This study relied on a prospective cohort, initiated in 1991-1993 (T1) with two follow-ups after 8 years (T2, 1999-2000) and 24 years (T3, 2015-2018). Participants (N=1,629) were randomly selected for arterial stiffness measurement at T3 using carotid-femoral pulse wave velocity (PWV). Long working hours (>40 h/week) were assessed at baseline (T1) and at the first follow-up (T2). Mean differences in PWV were estimated using generalized linear models, accounting for sociodemographic factors, lifestyle-related risk factors, clinical factors and psychosocial stressors at work. Results: Among participants who remained actively employed over the study period, baseline (+0.54 m/s, 95% CI: 0.05 – 1.02) and repeated (+1.54 m/s, 95% CI: 0.83 – 2.26) exposures to long working hours were associated with increased arterial stiffness. No association was observed among participants who retired between follow-ups. Conclusions: Working long hours during midlife is associated with increased arterial stiffness, among aging workers. Workplace preventive strategies reducing long working hours may be effective to mitigate long-term arterial stiffening.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".