Dosimetric Evaluation of Hippocampus Sparing Intensity Modulated Radiation Therapy in Patients With Stage T1-T2 and Stage T3-T4 Nasopharyngeal Carcinoma
Bibliographic record
Abstract
Purpose To compare the hippocampus (HPC) dose reduced by HPC-sparing intensity modulated radiation therapy (IMRT) plans between nasopharyngeal carcinoma (NPC) patients of stages T1-T2 and T3-T4, and to investigate the correlation between the dose of the HPC and the volume of PTV nx70 (the planning target volume of the primary tumor in the nasopharynx that received 70 Gy). Methods and Materials Fifty-eight NPC patients were retrospectively evaluated. HPC-nonsparing IMRT or sparing IMRT for each patient was designed according to the protocol for NPC. Dose-volume histogram was used to evaluate the IMRT plans for each patient. The difference in values of HPC parameters (eg, D min [NS] – D min [S]) between HPC-sparing and nonsparing plans in the stage T1-T2 group and stage T3-T4 group were compared. The correlations between the dose of the HPC and the volume of PTV nx70 were analyzed. Results There was no significance between HPC-sparing and nonsparing IMRT plans. Compared with the HPC-nonsparing plans, the HPC-sparing plans significantly decreased both dosimetric and volumetric parameters for the HPC ( P < .05), except for D min , D 98%, and V 5 . The medians of D median [NS] – D median [S], D mean [NS] – D mean [S], D 40% [NS] – D 40% [S], V 30 [NS] – V 30 [S], V 40 [NS] – V 40 [S] and V 50 [NS] – V 50 [S] in the T1-T2 group were significantly lower than in the T3-T4 group ( P < .05), respectively. Both dosimetric and volumetric parameters for the HPC were positively correlated with the volume of PTV nx70 in HPC-sparing and HPC-nonsparing plans ( P < .05). The volume of PTV nx70 was positively correlated with D median [NS] – D median [S], D mean [NS] – D mean [S], D 40% [NS] – D 40% [S], V 40 [NS] – V 40 [S] and V 50 [NS] – V 50 [S] ( P < .05). Conclusions HPC-sparing IMRT plans may play a more significant role in decreasing D median , D mean , D 40%, and V 30 -V 50 of HPC in NPC patients with stages T3-T4 than those in stages T1-T2. PTV nx70 volume of NPC patients is positively correlated with all dosimetric and volumetric parameters of HPC and the reduction of specific dosage parameters by HPC-sparing IMRT plans.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".